Dr. Man Li, PHD, HCLD (ABB)

Tree of Life Center, Directeur du laboratoire de FIV

Le Dr Man Li est la directrice du laboratoire de FIV, le laboratoire de reproduction TLC du WC du Tree of Life Center.

Le docteur Li apporte des années d'expérience dans le laboratoire de FIV. Elle a suivi une formation de médecin en tant qu'obstétricien et gynécologue, puis une formation d'embryologiste clinique. Ses recherches portent depuis de nombreuses années sur les tests génétiques préimplantatoires unicellulaires. En ce qui concerne le laboratoire d'embryologie, le centre Tree of Life offre des services de pointe avec des scientifiques et des technologies de laboratoire de haut niveau. Soyez assurés que vos embryons seront pris en charge par certains des embryologistes les plus expérimentés de Californie. Le laboratoire est le cœur de la clinique de fertilité et la base de la réussite du processus de fécondation in vitro.

L'EXPÉRIENCE PROFESSIONNELLE ANTÉRIEURE :

2019 - 2020 Directeur de laboratoire au West Coast Fertility Center, Fountain Valley, Californie
2017 - 2019 Directeur de laboratoire au Western Fertility Institute, Encino, Californie
2006 - 2016 Directeur de laboratoire au Fertility and Surgical Associates of California, Thousand Oaks, Californie.
2003 - 2006 Directeur, diagnostic et recherche en génétique préimplantatoire, Southern Ca Reproductive Center, Beverly Hills, Californie.
2002 - 2003 Embryologiste principal et scientifique du laboratoire de DPI, Florida Institute for Reproductive Medicine, Jacksonsville, Floride.
1999 - 2002 Embryologiste et scientifique spécialiste du DPI, Laboratoire de FIV et de génétique des gamètes, Université de Gotenborg, Suède

ÉDUCATION :

Études post-doctorales à l'Université de Floride à Gainsville, Floride 1999-2002
Doctorat au centre de recherche et de médecine de la reproduction de l'université médicale Sun Yat-sen de Guangzhou, Chine 1994-1998
Résidence d'obstétrique et de gynécologie à l'Université médicale de Tongji à Wuhan, Chine 1990-1994
Tongji Medical University, Wuhan, China, 1985-1990

LES CERTIFICATIONS :

Directeur de laboratoire clinique de haute complexité (HCLD) dans les disciplines de l'embryologie (ELD), de l'andrologie et du diagnostic moléculaire, certifié par l'American Board of Bioanalysis (ABB), numéro de certificat 3488, décembre 2000.
Spécialiste de laboratoire certifié en biologie moléculaire (CLSMB), National Credentialing Agency for Laboratory Personnel (NCA, devenu ASCP), depuis août 2005.
Scientifique en biologie moléculaire génétique clinique de Californie (CGMBS), licence de l'État de Californie n° MTP00000365, depuis juillet 2012.

ADHÉSIONS :

Société américaine de médecine de la reproduction (ASRM), Membre 2001 - présent
Pacific Coast Reproductive Society (PCRS), Membre 2003 - présent
Société médicale chinoise de gynécologie et d'obstétrique, 1990 - présent

PUBLICATIONS:

1. M. Li, A Kumar. TESTICULAR SPERM CORRELATES WITH A SIMILAR RATE OF EUPLOID EMBRYO DEVELOPMENT COMPARED TO CYCLES USING EJACULATED SPERM .. Fertility and Sterility, ASRM 2016 presentation.

2. M. Li, A. Kumar, M. Shamonki, G. Hubert. Implantation rates following transfer of vitrified euploid blastocysts are independent of maternal age. Fertility and Sterility, Vol. 104, Issue 3, e33~340. September 2015.

3. Man Li MD PhD, Yufen Xie MD PhD, Hyang Park MS, Sanaz Azadbadi MS, Ashim Kumar MD, Gary Hubert MD, Richard Buyalos MD. Microarray Preimplantation Genetic Screen significantly improves clinical outcomes in patients received vitrified-thawed embryos transfer. ASRM 2014 oral presentation.

4. Yufen Xie MD PhD,Man Li MD PhD,Hyang Park MS, Sanaz Azadbadi MS, Ashim Kumar MD, Gary Hubert MD, Richard Buyalos MD. The Relationship Between Blastocyst Grading, Timing of Blastocyst Formation, Maternal Age and Chromosomal Abnormality. Fertility and Sterility, Vol. 102, Issue 3, e174. September 2014.

5. Richard Buyalos, Lian Liu, Ashim Kumar, Felicia Wetherby, Raul Leony, Man Li. Blastocysts Re-analysis after Cleavage Stage Biopsy with 24 Chromosome Array Comparative Genomic Hybridization (CGH). How Reliable Is the PGS Report? Fertility and Sterility, Vol. 99, Issue 3, S29-S30. March 01, 2013.

6. Richard Buyalos, Lian Liu, Ashim Kumar, Felicia Wetherby, Raul Leony, Man Li. Is Morula Biopsy an Effective Option for PGS? Fertility and Sterility, Vol. 99, Issue 3, S30. March 01, 2013.

7. F. Weatherby, S. Keyhan, A. Kumar, G. Hubert, R. Buyalos, M. Li. Oocyte bank set up by comparing different vitrification devices. Fertility and Sterility, Vol. 100, Issue 3, S174. September, 2013.

8. M. Li, Y. Xie, H. Park, A. Kumar, G. Hubert, R. Buyalos. Frozen-thawed embryo transfer improves clinical 01,.1tcomes in patients receiving IVF treatment. Fertility and Sterility, Vol. 100, Issue 3, S177. September, 2013.

9. M. Li, Y. Xie, H. Park, A. Kumar, G. Hubert, R. Buyalos. The effects of elevated serum progesterone level at the day of hCG injection on clinical outcome in IVF-ET patients. Fertility and Sterility, Vol. 100, Issue 3, S7. September, 2013.

10. R. Buyalos, M. Li, F. Miller, M. Zhang, A. Kumar, G. Hubert. Effective blastocyst cryopreservation markedly incre.ases cumulative pregnancy rates per ova retrieval in donor ova and non-donor cycles independent of patient age. Fertility and Sterility, Vol. 92, Issue 3, S157. September 2009.

11. R. Buyalos, M. Li, A. Kumar, G. Hubert, F. Miller. Does Advancing Maternal Age Ameliorate the Advantage of Blastocyst Transfer? The Implantation Rate of Blastocyst Compared to Cleavage Stage Embryo Transfer as a Function of Patient Age. Fertility and Sterility, Vol. 95, Issue 4, S13-S14. March 15, 2011.

12. Man Li, MD, PhD. Dual Differential Stain Protocol: Blastocyst Cell Discrimination and Number Determination. The Clinical Embryologist, 2006, Issue 2, Volume 9, P34-35.

13. Tian Chiu, Man Li, Catherine Marin De Ugarte, David Hill. Surrogate live birth of a normal baby for a patient with Marfan syndrome. Poster Presentation, PCRS 2005.

14. DL Hill, N Buehler, Z Jiang, M Surrey, H Danzer and Man Li. In Vitro Fertilization - Embryo Transfer Combined with Aneuploidy Screening of Day Three Embryos Lowers the Miscarriage Rate in Recurrent Pregnancy Loss Patients of Advanced Maternal Age. Poster Presentation, PCRS 2005.

15. Man Li, Catherine Marin DeUgarte, Mark Surrey, Hal Danzer, Alan DeChemey and David L. Hill. Fluorescence in situ hybridization reanalysis of day-6 human blastocysts diagnosed with aneuploidy on day 3. Fertility Sterility 2005; 11 :1395-1400.

16. Man Li MD PhD, Catherine Marin DeUgarte MD, Hal Danzer MD, Mark Surrey MD, and David Hill PhD. Determination of Mosaicism in early human embryos by confirmation FISH. Poster Presentation, PCRS 2005.

17. Man Li MD PhD, Catherine Marin DeUgarte MD, Hal Danzer MD, Mark Surrey MD, Alan DeCherney MD and David Hill PhD. Rescue ICSI and PGD: the combination can result in pregnancy. Poster Presentation, PCRS & ASRM 2005.

18. Catherine Marin DeUgarte MD, Gayane Ambartsumyan MD, Man Li MD PhD, David Hill PhD and Alan DeChemey MD. Successful selection of normal embryos using PGD in a woman with Spinocerebellar Ataxia Type 3. Poster Presentation, PCRS 2005.

19. David Hill PhD, Man Li MD PhD, Catherine Marin DeUgarte MD, Hal Danzer MD, Mark Surrey MD, and Alan DeCherney MD. Day 3 morphology as a predictor of aneuploidy. Poster Presentation, PCRS & ASRM 2005.

20. Susan Sarajari MD, Catherine Marin DeUgarte MD, Man Li MD PhD, Alan DeCherney MD and David Hill PhD. Aneuploidy in Day 3 embryos where in pronuclei (PN) were not observed following routine insemination or lntracytoplasmic sperm injection (ICSI). Poster Presentation, ASRM 2005.

21. David Hill PhD, Man Li MD PhD, Catherine Marin DeUgarte MD, Susan Sarajari MD, Nicole Buehler, Mark Surrey MD, Hal Danzer MD and Alan DeCherney MD. The relationship between cleavage rate and morphology to aneuploidy in day three human embryos. Poster Presentation, ASRM 2005.

22. Man Li, David Hill. FISH reanalysis on day 6 human blastocysts diagnosed with aneuploidy on day 3: does day 3 single cell biopsy accurately represent the numerical chromosomal status of the embryo? ESH RE 2004, oral presentation.

23. Man Li, David Hill. Embryo biopsy medium may hold the key to successful outcomes following pre-implantation genetic diagnosis. ESHRE 2004, poster presentation

24. Man Li MD PhD, Catherine Marin DeUgarte MD, Zharong Jiang MD, Hal Danzer MD, Mark Surrey MD, and David Hill PhD. Towards a single blastocyst transfer: PGD in combination with morphology selection could be the ultimate tool. ASRM 2004 Poster Presentation.

25. Man Li, MD, PhD, Catherine Marin De Ugarte, MD, Hal Danzer.MD, Mark Surrey MD, Alan DeCherney MD and David Hill, PhD. Comparison of Computer Assisted Infrared Laser with acid Tyrode solution in zona drilling for embryo biopsy. ASRM 2004 Poster presentation.

26. Man Li, Ashim Kumar, Catherine Marin DeUgarte, Mark Surrey, Hal Danzer, Alan DeCherney, David L. Hill. Does "EmbryoGlue®" help embryos in their implantation? ASRM 2004 Poster presentation.

27. Catherine Marin De Ugarte MD, Man Li MD PhD, Alan DeCherney MD, Hal Danzer MD, Mark Surrey MD, David Hill PhD. Accuracy of FISH in predicting chromosomal status in PGD patients. ASRM 2004 Poster presentation.

28. Catherine Marin De Ugarte MD, Man Li MD PhD, Alan DeCherney MD, Mark Surrey MD, Hal Danzer MD, David Hill PhD; Do patients who undergo Preimplantation Genetic 4 Diagnosis have higher pregnancy rates and should fewer embryos be transferred? ASRM 2004 poster presentation.

29. Jaime Drinville MD, Catherine Marin De Ugarte MD, Man Li MD PhD, David Hill PhD, Mark Surrey MD and Alan DeCherney MD. Are families with 3 children of the same sex more likely to have the next child of the same sex? ASRM 2004 poster presentation.

30. Man Li, David Hill. Pregnancies by PGD for translocation carriers using single interphase cell FISH with chromosome-specific breakpoint spanning probes. PCRS 2004, poster presentation.

31. David Hill and Man Li. What Regulations for Preimplantation Genetic Diagnosis? Journal of Assisted Reproductive Genetics, January 2004, Vol21, No. 1, P11-13

32. Kipersztok S, Man L, Drury KC, Williams RS, Rhoton-Vlasak AS. Use of lntracytoplasmic Sperm lnjectiopn (ICSI) in In-Vitro Fertilization (IVF) Cycles with Failed or Poor Fertilization. Reproductive Technologies. 2001, volume10, number 6;311-313.

33. Li M, Drury KC, Williams RS. Suitability of Mouse Embryos for Human IVF QC: Zygotes vs. 2-cell Embryos. Fertility and Sterility 2001, 76 (3S1): S230

34. Li M, Drury KC, Kipersztok S, Rhoton-Vlasak AS, Williams RS. Efficiency of 12- chromosome aneuploidy diagnosis (2,7,8,13,14,15,16,18,21,22, Y and Y) by three round FISH test. Fertility and Sterility 2002, 78, suppl1: s183.

35. Xu YW, Zhuang GL, Shu YM, Li M, Zhou CQ, Zhang MF. Preimplantation Gender diagnosis by fluorescence in situ hybridization. Chinese Medical Journal 2002; 115 (6): 874-877.

36. Li Man, Zhuang GL, et al. Using testicular sperm to provide fertility for azoospermia men. National medical journal of China, 2000,80 (8): 588-590.

37. Li Man, Zhuang GL, et al. Using ejaculated, epididymal or testicular spermatoza to provide fertility for infertile men. Journal of Chinese surgery, 2000,38(4): 280-282.

38. Li Man, Zhuang GL. Development potential of human embryos after blastomere biopsy. Journal of reproductive medicine (Chinese), 1999,8(2): 107-109.

39. Li Man, Zhuang GL, et al. Pregnancy after intracytoplasmic sperm injection using immotile, stump ejaculated and testicular spermatozoa. Journal of reproductive medicine (Chinese}, 2000,9 (3) 178-179.

40. Li Man, Zhuang GL, et al. Frozen-thawed epididymal sperm intracytoplasmic sperm injection to treat infertility caused by obstructive azoospermia. Journal of Chinese urology, 1999,20 (6): 350.

41. Li XH, Li M, Zhuang GL, et al. Sex determination of pre-implantation embryos by nest PCR. Academic Journal of Sun Yat-sen University of Medical Sciences. 1998,19 (1): 11- 13.

42. Li Man, Zhuang GL, et al. Cryopreservation noctoral emission and intracytoplasmic sperm injection to provide fertility for anejaculation men. Journal of reproductive medicine (Chinese}, 1998,7(1):52-53.

43. Li Man, Zhuang GL, et al. The relationship of serum P level on the day of hCG injection and pregnancy in in vitro fertilization and embryo transfer. Chinese Journal of practical Gynecology and Obstetrics. 1997,13 (3): 147-148.